Delivery systems for intravenous nitroglycerin

Delivery systems for intravenous nitroglycerin.

Effect of Intravenous Nitroglycerin

This study was performed to determine whether nitroglycerin (NG) can increase collateral flow to ischemic myocardium and reduce ultimate infarct size. Permanent occlusion of the mid-circumflex coronary artery was produced in 43 previously instrumented conscious dogs and within 3 minutes, 6-hour intravenous infusions were begun of saline (controls, n = 18), NG in doses to reduce mean arterial pr...

The Effects of Intravenous Nitroglycerin

group of biologically active compounds derived from prostaglandin endoperoxides. Proc Nat Acad Sci USA 72: 2994, 1975 25. Needleman PS, Moncada S, Bunting S, Vane JR, Hamberg M, Samuelsson B: Identification of an enzyme in platelet microsomes which generates thromboxane A2 from prostaglandins. Nature 261: 558, 1976 26. Ellis EA, Oelz 0, Roberts LJ, Payne NA, Sweetman BJ, Nies AS, Oates JA: Coro...

Heparin Resistance During and Post-Intravenous Nitroglycerin Infusion

      Nitroglycerin has been reported to reduce activated partial thromboplastin time (aPTT) values in patients treated with concurrent heparin and nitroglycerin. However, studies have yielded conflicting results. To determine whether intravenous nitroglycerin alters the anticoagulant effect of heparin, we prospectively evaluated twenty patients admitted for coronary angioplasty by measurin...

Intravenous Nitroglycerin in Acute Myocardial Infarction

Vasodilator therapy has been shown to improve ventricular function in patients with left ventricular failure complicating acute myocardial infarction. Sublingual nitroglycerin also improves ventricular function in these patients but its effects are transient and variable. Infusion of intravenous nitroglycerin in 12 patients with acute infarction resulted in a decrease in left ventricular fillin...